Professor at National Tsing Hua University, Taiwan
Dr. Cheng-Hsien Liu is a distinguished academic and researcher holding a Ph.D. in Mechanical Engineering from Stanford University, USA, and an M.S. in Electrical Engineering from the same institution. He currently serves as a Professor in the Department of Power Mechanical Engineering and the Institute of NanoEngineering and MicroSystem at National Tsing Hua University, Taiwan. With extensive experience, Dr. Liu has contributed significantly to various research fields, particularly in the intersection of engineering, nanoengineering, and microsystems.
Author Metrics:
Chenghsien Liu is affiliated with Stanford University in the United States. He has a Scopus, Orcid.
Scopus Profile
Orcid Profile
Here are some metrics associated with Chenghsien Liu’s scholarly contributions:
- Citations: 2,271 citations from 1,949 documents.
- Documents: 175 publications.
- h-index: 23.
The h-index is a measure of both the productivity and citation impact of a researcher’s publications. An h-index of 23 indicates that there are 23 publications by the author that have each been cited at least 23 times.
Education:
Dr. Liu earned his Ph.D. in Mechanical Engineering from Stanford University in 2000 and his M.S. in Electrical Engineering in 1995, showcasing a strong foundation in both mechanical and electrical aspects of engineering.
Research Focus:
His research focuses on cutting-edge areas, including personalized precision drug screening lab chips, cancer immunotherapy utilizing lung-on-chip technology, and capturing complex liver tissue functions in vitro using liver-on-chip platforms. These endeavors demonstrate his commitment to advancing biomedical engineering and technology.
Professional Journey:
Dr. Liu’s professional journey has been marked by significant academic contributions. Starting as an Assistant Professor in Power Mechanical Engineering at National Tsing Hua University in 2000, he has risen through the ranks, holding positions such as Associate Professor and Division Head. His leadership roles include serving as Chairman of the International Intercollegiate Ph.D. Program and as Chief Executive Officer of the Industrial Liaison Program at the College of Engineering.
Honors & Awards:
His exceptional contributions have been acknowledged through prestigious awards, including the National Innovation Award (Taiwan Healthcare) in 2022 and 2021, the “Grass Roots” Award from Boehringer Ingelheim in 2021, and the 1st place Award in the 2021 Program Review of MOST Automation Engineering Program.
Publications Top Noted & Contributions:
Dr. Liu has made impactful contributions to the scientific community, with notable publications in journals such as Sensors & Actuators: B. Chemical and Lab on a Chip. His work spans diverse topics, from finger-powered cell-sorting microsystem chips to liver-cell patterning lab chips, showcasing a breadth of expertise.
Background and Motivation:
The combination of chemotherapy and immunotherapy is considered a promising approach for treating cancer patients.
The Keynote-189 phase III clinical trial demonstrated reduced mortality with the combination of chemotherapy and immunotherapy compared to chemotherapy alone.
The underlying mechanisms of this treatment combination are not well understood.
Objective and Approach:
The study aims to provide insights into the mechanisms of chemo/immunotherapy through the use of a “Tumor-on-a-Chip” system.
The Tumor-on-a-Chip system is designed to mimic the tumor microenvironment (TME) in an in-vitro lung cancer-immune model.
Tumor-on-a-Chip Design:
Gelatin methacryloyl (GelMA)-cancer cells are used to form a tumor-like hydrogel on an ITO electrode track.
Liquid dielectrophoresis (LDEP) is employed to drive the GelMA-cancer cells onto the electrode track.
Jurkat T cells are placed around the solidified GelMA-A549 cells, creating a structure resembling the cancer-immune microenvironment.
Stimulation of Immune-Cell Infiltration:
Immune-cell infiltration into the tumor is activated and enhanced using either IL-1β-treated A549 cells or atezolizumab (an immune drug) on the Tumor-on-a-Chip.
Results:
The study reports a significant increase of approximately 35% in the death of cancer cells after chemo/immunotherapy combination treatment compared to single treatments.
The distribution of dead cancer cells treated with chemo/immunotherapy reveals distinct theoretical mechanisms.
Implications and Conclusion:
The findings suggest a potential application of the Tumor-on-a-Chip system for personalized medicine treatments in cancer patients.
The Tumor-on-a-Chip system offers a platform for studying the effects of chemo/immunotherapy combinations on immune-cell infiltration and cancer cell death.
Title: A High Throughput Biocompatible Insulator Based Dielectrophoretic (iDEP) Lab Chip for Patterning and Fusion of Biological Cells
- Journal: Sensors and Actuators B: Chemical
- Year: 2022
- DOI: 10.1016/j.snb.2021.131109
- Contributors: G. Pendharkar, Y.-T. Lu, C.-M. Chang, M.-P. Lu, C.-H. Liu
- Detail: This article presents a high-throughput lab chip utilizing biocompatible insulator-based dielectrophoresis (iDEP) for the efficient patterning and fusion of biological cells. The work contributes to the field of microsystems and cell manipulation technologies.
Title: A Microfluidic Chip Sorting Cd14+ Myeloid Cells from Whole Blood and Auto-Quantifying Monocyte Hla-Dr Expression on Chip
- Source: SSRN
- Year: 2022
- Contributors: C.-Y. Chou, Y.-T. Lu, C.-M. Chang, C.-H. Liu
- Detail: This work, available on SSRN, describes a microfluidic chip designed for sorting Cd14+ myeloid cells from whole blood. The chip is further capable of auto-quantifying monocyte Hla-Dr expression, providing a valuable tool for cell analysis.
Title: Finger-Powered Cell-Sorting Microsystem Chip for Cancer-Study Applications
- Source: SSRN
- Year: 2022
- Contributors: Y.-S. Lee, Y.-T. Lu, C.-M. Chang, C.-H. Liu
- Detail: This article introduces a finger-powered cell-sorting microsystem chip designed for cancer-study applications. The chip’s innovative design allows for efficient cell sorting, contributing to advancements in cancer research.
Title: Optofluidic Thin-film Lithography for Photocrosslinking Hydrogel-based Microarchitectures and the Assembling of Modular Cell-embedded Microarchitectures
- Journal: Sensors and Actuators B: Chemical
- Year: 2022
- DOI: 10.1016/j.snb.2021.131048
- Contributors: Y.-S. Chen, L.-Y. Ke, S.-Y. Wei, M.S. Poddar, C.-H. Liu
- Detail: This article, published in Sensors and Actuators B, explores optofluidic thin-film lithography for photocrosslinking hydrogel-based microarchitectures. The study focuses on assembling modular cell-embedded microarchitectures, offering insights into advanced fabrication techniques.
Title: Microfluidic Microalgae System: A Review
- Journal: Molecules
- Date: 2022-03-15
- DOI: 10.3390/molecules27061910
- Contributors: A. Baby Alias, S. Mishra, G. Pendharkar, C.-S. Chen, C.-H. Liu, Y.-J. Liu, D.-J. Yao
- Detail: This review, published in the journal Molecules, provides an overview of microfluidic microalgae systems. The collaborative work offers insights into the current state of research in this field.
Research Timeline:
Throughout his career, Dr. Liu’s research timeline reflects a continuous dedication to advancing technology in areas ranging from optofluidic thin-film lithography to cancer immunotherapy microenvironment lab chips. His trajectory demonstrates a commitment to innovation and scientific exploration.
In summary, Dr. Cheng-Hsien Liu stands as a distinguished figure in the field of engineering and biomedical research, with a strong academic foundation, leadership roles, and a rich portfolio of impactful contributions to scientific literature and technological advancements.
