Dr. Yinghao Li is a dedicated Ph.D. researcher specializing in Polymer Design and Engineering at the Charles Institute of Dermatology, School of Medicine, University College Dublin. His research focuses on unraveling the complex relationships between polymer structure, properties, and practical applications. With a strong foundation in chemistry, materials science, and computer simulation, Dr. Li is committed to designing multifunctional materials for various applications, particularly in gene therapy. His extensive academic journey includes significant contributions to the field of polymer science and valuable industry experience.
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- Dr. Li’s publications have garnered a total of 565 citations on Google Scholar, attesting to the impact and relevance of his research in the scientific community.
Citations: 65 citations from 60 documents.
Documents: Author of 17 documents.
h-index: H-index of 3.
Education
Ph.D. Materials Science and Engineering
School of Medicine, University College Dublin, Dublin, Ireland
October 2019 – July 2023
B.S. Polymer Science and Engineering
South China University of Technology, Guangzhou, China
September 2014 – July 2018
Research Focus
Dr. Li’s research encompasses macromolecular design, synthesis, and structure control, with a specific focus on cyclized and hyperbranched polymers and their hydrogels. His work also includes the development of polymeric delivery vectors for bio-applications, such as gene, RNA, and drug delivery. Additionally, he explores the creation of multifunctional photo-responsive materials.
Professional Journey
Dr. Li’s professional journey includes research assistant positions in prominent labs, early-career research at a biotechnology company, and extensive doctoral studies at the University College Dublin. His industry experience at Branca BunĂşs Ltd involved the development and commercialization of polymer-based gene therapeutics for genetic disorders. Dr. Li’s leadership roles in laboratory management further showcase his commitment to advancing research.
Honors & Awards
UCD Conway Festival Gold Medal Competition (2023):
Awarded for the oral presentation on “3D Macrocyclic Structure Boosted Gene Delivery.”
Publications Top Noted & Contributions
Dr. Li has authored 28 peer-reviewed papers, with 12 as first or co-first author, published in renowned journals such as ACS Nano and Angewandte Chemie International Edition. Notable contributions include the discovery of a new structural factor in branched polymers and the development of topological polymers for enhanced gene therapy.
“Enhanced gene transfection efficacy and safety through granular hydrogel mediated gene delivery process”
- Acta Biomaterialia, 2023-08
- DOI: 10.1016/j.actbio.2023.04.041
- Contributors: Jing Zhang, Zhonglei He, Yinghao Li, Yu Shen, Guanfu Wu, Laura Power, Rijian Song, Ming Zeng, Xianqing Wang, Irene Lara Sáez, et al.
“3D Macrocyclic Structure Boosted Gene Delivery: Multi-Cyclic Poly(β-Amino Ester)s from Step Growth Polymerization”
- Journal of the American Chemical Society, 2023-08-09
- DOI: 10.1021/jacs.3c04191
- Contributors: Yinghao Li, Xianqing Wang, Zhonglei He, Melissa Johnson, Sigen A, Irene Lara-Sáez, Jing Lyu, Wenxin Wang
“Artificial Intelligence (AI)-Aided Structure Optimization for Enhanced Gene Delivery: The Effect of the Polymer Component Distribution (PCD)”
- ACS Applied Materials & Interfaces, 2023-08-02
- DOI: 10.1021/acsami.3c05010
- Contributors: Yinghao Li, Zhonglei He, Sigen A, Xianqing Wang, Zishan Li, Melissa Johnson, Ruth Foley, Irene Lara Sáez, Jing Lyu, Wenxin Wang
“Where is the induction from? Effect of disproportionation and comproportionation in Cu(0)-mediated reversible deactivation radical polymerization”
- Polymer, 2023-07
- DOI: 10.1016/j.polymer.2023.126055
- Contributors: Jing Lyu, Yongpeng Miao, Zishan Li, Yinghao Li, Yongsheng Gao, Melissa Johnson, Hongyun Tai, Wenxin Wang
“Controlled Polymerization of Acrylamide via One-Pot and One-Step Aqueous Cu(0)-Mediated Reversible-Deactivation Radical Polymerization”
- Macromolecules, 2023-07-11
- DOI: 10.1021/acs.macromol.3c00343
- Contributors: Zishan Li, Jing Lyu, Yinghao Li, Bei Qiu, Melissa Johnson, Hongyun Tai, Wenxin Wang
Research Timeline
- Ph.D. Studies (October 2019 – July 2023):
- Investigated poly(β-amino ester)s, step-growth polymerization mechanisms, and precise polymer structure control.
- Research Assistant at Prof. Wenxin Wang Lab (July 2021 – Present):
- Contributing to the development of multifunctional single-chain cyclized/knot polymers for wound healing in Recessive Dystrophic Epidermolysis Bullosa.
- Early Career Researcher at Branca BunĂşs Ltd (October 2021 – Present):
- Focused on the development of highly-branched poly (β-amino ester)s (PAEs)-based non-viral gene delivery vectors.
