Research Focus:

Dr. Takeshi Onoue’s primary research focus revolves around the mechanism of paradoxical low-flow, low-pressure gradient severe aortic stenosis and its association with reduced oxygen consumption by the whole body. His work includes investigations into the impact of various medications, such as metformin and SGLT2 inhibitors, on heart failure in patients with diabetes receiving anthracycline chemotherapy. Additionally, he explores novel noninvasive methods for estimating mixed venous oxygen saturation and provides insights into the transition from normal-flow high-pressure gradient severe aortic stenosis to paradoxical low-flow low-pressure gradient severe aortic stenosis.

Professional Journey:

Dr. Onoue’s professional journey showcases a progressive climb within the field of cardiology. Starting as a Junior Resident at Chubu Rousai Hospital in 2009, he has held various positions, including Senior Resident, Staff Physician, Assistant Professor, and ultimately attaining the role of Senior Lecturer at the Department of Cardiology, University of Occupational and Environmental Health. His international exposure as a Visiting Scholar at the University of Pennsylvania demonstrates a commitment to expanding his expertise and collaborating on a global scale.

Honors & Awards:

• 2019: Young Investigator’s Award – Japanese Society of Echocardiography
• 2019: Distinguished Abstract Award for Overseas Congress – Japanese Society of Echocardiography
• Other: STOP-CA Randomized Clinical Trial – Contributed to a noteworthy study

Publications & Contributions:

First Author Publications:

1. Association of metformin with heart failure in patients with diabetes receiving anthracycline chemotherapy.
2. SGLT2 inhibitors improved cardiac failure by reducing whole-body oxygen demand.
3. Novel noninvasive estimation of mixed venous oxygen saturation by echocardiography and expired gas analysis.
4. Case study: Change from normal-flow high-pressure gradient severe aortic stenosis to paradoxical low-flow low-pressure gradient severe aortic stenosis.
5. Insights into the mechanism of paradoxical low-flow, low-pressure gradient severe aortic stenosis.
6. Müller Maneuver as a tool for stress echocardiography.

Co-author Publications:

1. Atorvastatin for anthracycline-associated cardiac dysfunction: The STOP-CA Randomized clinical trial.
2. Potential mechanism of left ventricular spherical remodeling: Association of mitral valve complex-myocardium longitudinal tissue remodeling mismatch.
3. Possible mechanism of late systolic mitral valve prolapse: Systolic superior shift of leaflets secondary to annular dilatation.
4. Surgical as opposed to transcatheter aortic valve replacement improves basal interventricular septal hypertrophy.
5. Impact of image quality on reliability of measurements of left ventricular systolic function and global longitudinal strain.
6. Left atrial remodeling in segmental vs. global mitral valve prolapse.

Research Timeline:

• 2009-2011: Junior Resident at Chubu Rousai Hospital
• 2011-2013: Senior Resident at Kyushu Rousai Hospital
• 2013-2014: Senior Resident, Department of Cardiology, University of Occupational and Environmental Health
• 2015-2018: Fellow, Department of Cardiology, University of Occupational and Environmental Health
• 2018-2019: Assistant Professor of Medicine, Department of Cardiology, University of Occupational and Environmental Health
• 2021-2023: Visiting Scholar, Department of Cardiology, University of Pennsylvania
• 2023-present: Senior Lecture, Department of Cardiology, University of Occupational and Environmental Health

Dr. Takeshi Onoue’s research journey has evolved from residency to fellowships, academic appointments, and international collaborations, with a strong focus on understanding severe aortic stenosis and its clinical implications. His honors and awards highlight recognition within the field, while his diverse publications underscore his contributions to advancing cardiovascular knowledge.